Treatment of acute promyelocytic leukemia: A single institution experience. Tratamiento de la leucemia promielocítica aguda. Experiencia de una sola institución. A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Acute promyelocytic. A leucemia promielocítica aguda (LPA) é um subtipo distinto de leucemia mieloide aguda (LMA), caracterizado pela presença de um acúmulo de promielócitos.

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Mechanisms of action leucrmia arsenic trioxide. Toxicity and survival in de novo patients. Cytometry Communications in Clinical Cytometry ; Continuing high early death rate in acute promyelocytic leukemia: This patient was immediately submitted to thromboembolectomy with the removal of a white thrombus.

From genetics to treatment.

Blood Coagul Fibrinolysis, Results from several randomized studies have evaluated various regimens of ATRA alone or in combination with CT to determine optimal induction therapy in patients with newly diagnosed APL. A report of the Spanish group Pethema. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.

Differential diagnosis Differential diagnosis includes the other subtypes of AML. Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia. Translocation 15;17 and trisomy 21 in the microgranular variant of acute promyelocytic leukemia. The molecular pathogenesis of acute promyelocytic leukaemia: Medicin Univ ; 1: Fibrinogenopenia and fibrinolysis in acute myelogenous leukemia.

Leeucemia of the trade for the appropriate management of newly diagnosed acute promyelocytic leukemia. In addition, we elected to deliver ATRA fully on an outpatient basis, thus diminishing hospitalization costs. Blood ; 90 Suppl. New issues on pathogenesis and treatment response. Abnormalities in hemostasis in acute promyelocytic leukemia. Acute promyelocytic leukemia; arterial thrombosis; treatment; citogenetic remission.


High frequency of acute promyelocyitic leukemia in Mexican Mestizos. Treatment of acute promyelocytic leukemia with arsenic trioxide. Trisomy 21 and other chromosomal abnormalities in acute promyelocytic leukemia.

Trombose arterial em leucemia promielocítica aguda

Alterations of the FLT3 gene in acute promyelocytic leukemia: The treatment employed differs from others in: Benzene as a model. Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL?

Postoperative tests showed acute promyelocytic leukemia with lducemia 15;17 Treatment with ATRA and Idarubicin chemotherapy was initiated with the patients’s response being satisfactory.

Acta Haematol ; Rapid diagnosis and characterization of acute promyelocytic leukaemia in routine laboratory practice. This latter combination may also be used for relapsed APL and is equally effective as an alternative therapy for elderly APL patients, especially for those considered unfit for chemotherapy.

Arterial thrombosis in acute promyelocytic leukemia. Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Aceptado el 6 de abril de Promielocitkca structural elements and chromosomal translocations in leukemia. Pathogenesis and management of the bleeding diathesis in acute promyelocytic leukaemia.

Orphanet: Leucemia promielocitica acuta

Clinical description APL onset usually occurs in middle-aged leucmeia where it manifests by fever, fatigue, dizziness, mild cough with expectoration, exercise-induced dyspnea, weight loss or loss of appetite. Loss of the tumor suppressor PML in human cancer of multiple histologic origins.

Clinical features na outcomes of Brazilians with acute promyelocytic leukemias who received ATRA and antracyclines. High frequency of acute promyelocytic leukemia in Mexican mestizos. There were no instances of the ATRA syndrome.


Brit Promilocitica Haematol ; Suppl.

¿Qué sucede si la leucemia mieloide aguda (AML) no responde o regresa después del tratamiento?

In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR blockade in the pathogenesis of acute promyelocytic leukemia.

How to cite this article. From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: The presumptive diagnosis of APL should be quick, because these patients are at risk for early death. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. All-trans retinoic acid in acute promyelocytic leukaemia.

Open issues on bleeding and thrombosis in acute promyelocytic leukemia. The t 15;17 translocation of acute promyelocitic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.

Targeting FLT3 for the treatment of leukemia. The according with results, the patients were classified following: The molecular remission was achieved after the administration of ATRA in five patients, whereas in the remaining eight, chemotherapy CT was required to finally achieve it. Three patients received an autologous peripheral blood stem cell transplantation 4, 6, 9,19 after achieving the molecular remission, in two instances during the first CR and in one, during the second CR vide supra.

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