Citicoline is a medicine available in a number of countries worldwide. A list of US medications equivalent to Citicoline is available on the website. Choline C 11 Injection, for intravenous use. Initial U.S. Approval: INDICATIONS AND USAGE Choline C The Federal Food, Drug, and Cosmetic Act requires that manufacturers and distributors who wish to market dietary supplements that contain.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Minor transient adverse effects are rare and most commonly include stomach pain and diarrhea. Retrieved from ” https: The brain preferentially uses choline to synthesize acetylcholine. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.

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Citicoline wins EU novel foods approval – in medical foods and food supplements

Phosphatidylcholine is a major phospholipid in eukaryotic cell membranes. This can lower levels of hydroxyl radicals produced after an ischemia and prevent cardiolipin from being catabolized by phospholipase A2. Further information on drug naming conventions: The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelinpreservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolaminepartial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.


Cytidine citicolne trihydrogen diphosphatemono[2- trimetylammonio etyl] ester, hydroxide, inner salt. Cholinergics Nootropics Nucleotides Quaternary ammonium compounds Choline esters. The Journal of Biological Chemistry. From Wikipedia, citicokine free encyclopedia.

Muscarinic acetylcholine receptor modulators. Citicoline lowers increased glutamate concentrations and raises decreased ATP concentrations induced by ischemia. The Complete Drug Reference [ed. Home International Citicoline Print Share. Citicoline is available as a supplement online and in stores.

This limits the amount of choline available to synthesize phosphatidylcholine. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. A review of published clinical trials of citicoline noted that while some studies have demonstrated positive effects of the compound on cognition, other studies have failed to confirm these results and additional clinical trials would be needed to cigicoline any potential benefits of citicoline.

This means it is still under development and may contain inaccuracies. The effect of citicoline on visual function citiciline been studied in patients with glaucoma. Reviews in Neurological Diseases.

British Journal of Pharmacology. A meta-analysis of randomized controlled trials”. Consult with your healthcare professional before taking any medication.

Citicoline | C14H26N4O11P2 – PubChem

Int J Mol Sci. Citkcoline view content sources and attributions, please refer to our editorial policy. Studies suggest that CDP-choline supplements increase dopamine receptor densities.

This page was last edited on 14 Septemberat Citicoline INNalso known as cytidine diphosphate-choline CDP-Choline or cytidine 5′-diphosphocholine is an intermediate citicolije the generation of citicolind from cholinea common biochemical process in cell membranes. We comply with the HONcode standard for trustworthy health information – verify here.


It is sold in over 70 countries under a variety of brand names: Despite some suggestions that citicoline may reduce the rates of death and disability following an ischemic stroke[10] [11] the largest citicoline clinical trial to date, a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke in Europe, enrolling patients, found no benefit of administering citicoline on survival or recovery from stroke.

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Citicoline enhances cellular communication by increasing the availability of neurotransmitters, including acetylcholinenorepinephrineand dopamine. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional.


When the availability of choline is low or the need for acetylcholine increases, phospholipids containing choline can be catabolized from neuronal membranes. These phospholipids include sphingomyelin and phosphatidylcholine. Journal of Neuroscience Research. Views Read Edit View history. London UK ; e-version. Subscribe to free Drugs.

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