Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.
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The DFS was calculated as the time interval between the date of first treatment and the date of local disease recurrence or last information for censored observations when the patient was known to be disease-free.
Although this current investigation was limited by a relatively small sample size, there was a long follow-up period in which we could verify and confirm the influence of some prognostic factors. The clinicopathologic features and results of log rank tests for clinical variables are shown in tables 1 and 2respectively.
This study aimed to investigate prognostic factors that may affect survival in patients with a primary mucepidermoide of head and neck mucoepidermoid carcinomas.
Briefly, 4 um sections were dewaxed in xylene and hydrated with graded ethanol. Expression of c-erbB-2 oncoprotein in salivary gland tumours: It is composed of mucous, epidermoid, intermediate, columnar and clear cells. The medical and surgical records of all cases were reviewed for clinicopathological factors, such as age, gender, primary tumor location, tumor size, clinical stage, histological grade, treatment, compromised surgical margins, tumor recurrence, metastasis, disease-free survival DFS and overall survival OS.
Mucoepidermoid carcinoma of intraoral salivary glands. Besides, in the present study a standardized method was employed for evaluation of positivity.
Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
Sinonasal carinoma maxillary tumors were not included in the sample. MEC was prevalent in the female gender Considering the results in the sakivales sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of clinicopathological features such as patient age and gender and site or histological grades of the lesions.
Data concerning survival recurrence and metastasis were evaluated. However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al.
Through a long follow-up period in present study was highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. The use of skim milk as an economical and effective substitute for commercial biotin solutions. Oral Oncology, 41 1: International Journal of Morphology.
Lgandulas and immunohistochemical study of intraoral mucoepidermoid carcinoma.
However, in the study of Lopes et al. Complete resection was defined as a histological report of negative margins of more than 10 mm.
All positive cases also expressed cytoplasmic staining. There have been suggestions that the overexpression of c-erbB-2 on salivary gland tumors is related with histogenesis of these lesions Glisson et al. Ann Otol Rhinol Laryngol. Otolaryngol Head Neck Surg. This provides further support to the existence of distinct molecular mechanisms in salivary gland carcinogenesis associated with the overexpression of c-erbB Survival curves were generated using the Kaplan-Meier method and analyses were performed using the log rank test.
Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases.
The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively. Due to the singularity and diverse histology of these salivaoes, prognostic factors have been difficult to elucidate.
R; Dempsey, R J. In salivalss series the results were similar with 21 There were no statistically significant differences for any analyzed variable affecting OS curves. Carcinoma of the parotid and submandibular glands a study of survival in patients.
Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples.
Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. The reactions carvinoma revealed by applying 0. Concerning MEC, there had been only individual case descriptions of c-erbB-2 expression Kernohan et al.
Tumors were stratified into three groups: High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al.
Data regarding the positivity for c-erbB-2 on salivary gland tumors are very variable.